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Oxidative species are short\u2010lived species, which makes direct, precise, and real\u2010time measurements difficult. Herein, we report a novel core\u2013satellite gold nanostructure for dual, ratiometric surface\u2010enhanced Raman scattering (SERS) and photoacoustic (PA) imaging to enable the precise detection of inflammation\/cancer\u2010related H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . The combination of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010activated second near\u2010infrared (NIR\u2010II) PA imaging and SERS imaging enables the differentiation between the inflamed region and normal tissue with high accuracy. The mesoporous silica shell of the nanoprobe could be used to deliver drugs to the target area to precisely treat disease. Therefore, this core\u2013satellite nanostructure can not only quantitatively and precisely monitor H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    produced in inflammation, tumor, and osteoarthritis in rabbits in real\u2010time, but can also be used to track the progress of the anti\u2010inflammatory treatment in real\u2010time.\n                  <\/jats:p>","DOI":"10.1002\/anie.202015451","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T12:34:29Z","timestamp":1606998869000},"page":"7323-7332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":147,"title":["Dual Ratiometric SERS and Photoacoustic Core\u2013Satellite Nanoprobe for Quantitatively Visualizing Hydrogen Peroxide in Inflammation and Cancer"],"prefix":"10.1002","volume":"60","author":[{"given":"Qingqing","family":"Li","sequence":"first","affiliation":[{"name":"MOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University  Fuzhou 350116 P. 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