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These Cu\u2010catalyzed coupling of phenols with aryl bromides occurred with turnovers up to 8000, a value which is nearly two orders of magnitude higher than those of prior couplings to form biaryl ethers and nearly an order of magnitude higher than those of any prior copper\u2010catalyzed coupling of aryl bromides and chlorides. This ligand also led to copper systems that catalyze the coupling of aryl chlorides with phenols and the coupling of aryl bromides and iodides with primary benzylic and aliphatic alcohols. A wide variety of functional groups including nitriles, halides, ethers, ketones, amines, esters, amides, vinylarenes, alcohols and boronic acid esters were tolerated, and reactions occurred with aryl bromides in pharmaceutically related structures.<\/jats:p>","DOI":"10.1002\/anie.202015654","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T12:00:40Z","timestamp":1609329640000},"page":"8203-8211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Oxalohydrazide Ligands for Copper\u2010Catalyzed C\u2212O Coupling Reactions with High Turnover Numbers"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-5864","authenticated-orcid":false,"given":"Ritwika","family":"Ray","sequence":"first","affiliation":[{"name":"Department of Chemistry University of California Berkeley CA 94720 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