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The method employs nitrosobenzene as a reagent to drive the simultaneous activation of the boronic acid as a boronate and the activation of the C\u2212H bond of the aldehyde as an iminium species that triggers the key C\u2212C bond\u2010forming step via an intramolecular migration from boron to carbon. These findings constitute a practical, scalable, and operationally straightforward method for the synthesis of ketones.<\/jats:p>","DOI":"10.1002\/anie.202015835","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T15:24:05Z","timestamp":1611242645000},"page":"8728-8732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis of Ketones by C\u2212H Functionalization of Aldehydes with Boronic Acids under Transition\u2010Metal\u2010Free Conditions"],"prefix":"10.1002","volume":"60","author":[{"given":"Silvia","family":"Roscales","sequence":"first","affiliation":[{"name":"Instituto Pluridisciplinar Universidad Complutense Campus de Excelencia Internacional Moncloa  Paseo de Juan XXIII, 1 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-2231","authenticated-orcid":false,"given":"Aurelio G.","family":"Cs\u00e1ky","sequence":"additional","affiliation":[{"name":"Instituto Pluridisciplinar Universidad Complutense Campus de Excelencia Internacional Moncloa  Paseo de Juan XXIII, 1 28040 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,5]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar300054e"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf035149j"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.1846"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00017a013"},{"key":"e_1_2_2_6_1","unstructured":"\u00a0"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527613267"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/a800646f"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18011188"},{"key":"e_1_2_2_10_1","unstructured":"See reference\u2005[2] and in addition:"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)91316-4"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr040695c"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1268"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00039a007"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr900096x"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15109f"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201402509"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(99)00184-2"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2013.02.017"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506446"},{"key":"e_1_2_2_20_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201506446"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC08507A"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b00134"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b05205"},{"key":"e_1_2_2_24_1","unstructured":"For some additional recent methods see:"},{"key":"e_1_2_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201906000"},{"key":"e_1_2_2_25_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201906000"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC04062B"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002271"},{"key":"e_1_2_2_27_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202002271"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17224-2"},{"key":"e_1_2_2_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202000112"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15878-6"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB01458C"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja409241h"},{"key":"e_1_2_2_33_1","unstructured":"For the Corey-Seebach reaction see:"},{"key":"e_1_2_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196510771"},{"key":"e_1_2_2_34_3","first-page":"1136","volume":"77","year":"1965","journal-title":"Angew. 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