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Mechanistic studies revealed that the catalytically generated enamine is a key intermediate in the catalytic cycle. The developed method can be used to synthesize substituted 1,4\u2010dicarbonyl compounds containing quaternary carbons bearing various alkyl chains.<\/jats:p>","DOI":"10.1002\/anie.202016051","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T18:50:02Z","timestamp":1617821402000},"page":"10620-10625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Direct \u03b1\u2010Tertiary Alkylations of Ketones in a Combined Copper\u2013Organocatalyst System"],"prefix":"10.1002","volume":"60","author":[{"given":"Ayako","family":"Kurose","sequence":"first","affiliation":[{"name":"Graduate School of Science and Engineering Yamaguchi University  2-16-1 Tokiwadai Ube Yamaguchi 755-8611 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Ishida","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering Yamaguchi University  2-16-1 Tokiwadai Ube Yamaguchi 755-8611 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goki","family":"Hirata","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering Yamaguchi University  2-16-1 Tokiwadai Ube Yamaguchi 755-8611 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2659-4826","authenticated-orcid":false,"given":"Takashi","family":"Nishikata","sequence":"additional","affiliation":[{"name":"Graduate School of Science and Engineering Yamaguchi University  2-16-1 Tokiwadai Ube Yamaguchi 755-8611 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(76)80117-7"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.32.786"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)81920-1"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00109-8"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol0481535"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9804543"},{"key":"e_1_2_2_8_1","unstructured":"Selected examples of cross-enolate couplings:"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC04395H"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01313"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610274"},{"key":"e_1_2_2_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201610274"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200603024"},{"key":"e_1_2_2_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200603024"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","first-page":"49","volume":"76","author":"Prim D.","year":"2012","journal-title":"Org. 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