{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:31:05Z","timestamp":1786663865488,"version":"build-2736575974"},"reference-count":80,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["File Number: DIA\/2018\/000018"],"award-info":[{"award-number":["File Number: DIA\/2018\/000018"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007780","name":"Indian Institute of Science","doi-asserted-by":"publisher","award":["start up grant"],"award-info":[{"award-number":["start up grant"]}],"id":[{"id":"10.13039\/100007780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2021,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the construction of axially chiral C\u2212C bonds leading to the atroposelective synthesis of biaryls and allied compounds are well\u2010known, the related synthesis of compounds bearing axially chiral C\u2212N bonds are relatively rare. Described herein is the N\u2010heterocyclic carbene\u2010catalyzed atroposelective synthesis of N\u2010aryl succinimides having an axially chiral C\u2212N bond via the desymmetrization of N\u2010aryl maleimides. The NHC involved intermolecular Stetter\u2010aldol cascade of dialdehydes with prochiral N\u2010aryl maleimides followed by oxidation afforded N\u2010aryl succinimides in good yields and <jats:italic>ee<\/jats:italic> values. Preliminary studies on rotation barrier for the C\u2212N bond, the temperature dependence, and detailed DFT studies on mechanism are also provided.<\/jats:p>","DOI":"10.1002\/anie.202016938","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T15:54:26Z","timestamp":1616428466000},"page":"12264-12268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["NHC\u2010Catalyzed Desymmetrization of N\u2010Aryl Maleimides Leading to the Atroposelective Synthesis of N\u2010Aryl Succinimides"],"prefix":"10.1002","volume":"60","author":[{"given":"Soumen","family":"Barik","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Indian Institute of Science  Bangalore 560012 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Shee","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Indian Institute of Science  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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-8261","authenticated-orcid":false,"given":"Akkattu T.","family":"Biju","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Indian Institute of Science  Bangalore 560012 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"For reviews 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