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Here, we report the ultrasmall renal\u2010clearable luminescent gold nanoparticles (AuNPs) with both pH\u2010induced charge reversal and aggregation properties, and discover that enhanced ultrasound contrast could be facilely acquired through the increased tubular reabsorption and in situ aggregation of AuNPs in renal tubule cells in injured kidneys. The tuning elimination pathway of the renal\u2010clearable luminescent AuNPs is further demonstrated to provide a synergistical fluorescence and ultrasound imaging strategy for diagnosing early kidney injury with precise anatomical information.<\/jats:p>","DOI":"10.1002\/anie.202017273","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T22:06:17Z","timestamp":1614895577000},"page":"11713-11717","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Enhanced Ultrasound Contrast of Renal\u2010Clearable Luminescent Gold Nanoparticles"],"prefix":"10.1002","volume":"60","author":[{"given":"Yue","family":"Tan","sequence":"first","affiliation":[{"name":"Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510640 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