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Their two\u2010step modular synthesis, centered on the nucleophilic ring opening of an activated furan, makes DASAs readily accessible. However, the use of less reactive donors or acceptors renders the process slow and low yielding, which has limited their development. We demonstrate here that 1,1,1,3,3,3\u2010hexafluoro\u20102\u2010propanol (HFIP) promotes the ring\u2010opening reaction and stabilizes the open isomer, allowing greatly reduced reaction times and increased yields for known derivatives. In addition, it provides access to previously unattainable DASA\u2010based photoswitches and DASA\u2013polymer conjugates. The role of HFIP and the photochromic properties of a set of new DASAs is probed using a combination of <jats:sup>1<\/jats:sup>H\u2005NMR and UV\/Vis spectroscopy. 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