{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:29:24Z","timestamp":1791325764328,"version":"4.3.1"},"reference-count":88,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22074044"],"award-info":[{"award-number":["22074044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21705107"],"award-info":[{"award-number":["21705107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["No.SZSM202011014"],"award-info":[{"award-number":["No.SZSM202011014"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2021,5,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Schizophrenia (SZ) detection enables effective treatment to improve the clinical outcome, but objective and reliable SZ diagnostics are still limited. An ideal diagnosis of SZ suited for robust clinical screening must address detection throughput, low invasiveness, and diagnosis accuracy. Herein, we built a multi\u2010shelled hollow Cr\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    spheres (MHCSs) assisted laser desorption\/ionization mass spectrometry (LDI MS) platform for the direct metabolic profiling of biofluids towards SZ diagnostics. The MHCSs displayed strong light absorption for enhanced ionization and microscale surface roughness with stability for the effective LDI of metabolites. We profiled urine and serum metabolites (\u22481\u2005\u03bcL) with the enhanced LDI efficacy in seconds. We discriminated SZ patients (SZs) from healthy controls (HCs) with the highest area under the curve (AUC) value of 1.000 for the blind test. We identified four compounds with optimal diagnostic power as a simplified metabolite panel for SZ and demonstrated the metabolite quantification for clinic use. Our approach accelerates the growth of new platforms toward a precision diagnosis in the near future.\n                  <\/jats:p>","DOI":"10.1002\/anie.202101007","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T14:00:58Z","timestamp":1615816858000},"page":"12504-12512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Design of Multi\u2010Shelled Hollow Cr\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    Spheres for Metabolic Fingerprinting"],"prefix":"10.1002","volume":"60","author":[{"given":"Rongxin","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Psychiatric Rehabilitation Shenzhen Kangning Hospital Shenzhen Guangdong 518118 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Pei","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianzhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuhan Mental Health Center Tongji Medical College of Huazhong University of Science and Technology Wuhan Hubei 430032 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan Hubei 430070 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-2647","authenticated-orcid":false,"given":"Jingjing","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01121-6"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.28"},{"key":"e_1_2_6_3_1","unstructured":"\u00a0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.67"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30237-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30093-8"},{"key":"e_1_2_6_7_1","unstructured":"\u00a0"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000595"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00734-5"},{"key":"e_1_2_6_10_1","unstructured":"\u00a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.54"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.3637"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(20)30058-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200077"},{"key":"e_1_2_6_15_1","unstructured":"\u00a0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.131"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.12.008"},{"key":"e_1_2_6_18_1","unstructured":"\u00a0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21548"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4101"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.09.021"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2020.09.054"},{"key":"e_1_2_6_23_1","unstructured":"\u00a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202001135"},{"key":"e_1_2_6_24_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202001135"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202001714"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100901"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.03.010"},{"key":"e_1_2_6_28_1","unstructured":"\u00a0"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0220-4"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0353-x"},{"key":"e_1_2_6_31_1","unstructured":"\u00a0"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17347-6"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002021"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0AN00836B"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b01186"},{"key":"e_1_2_6_36_1","unstructured":"\u00a0"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2019.08.014"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201207348"},{"key":"e_1_2_6_38_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201207348"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b05074"},{"key":"e_1_2_6_40_1","unstructured":"\u00a0"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000906"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201913065"},{"key":"e_1_2_6_42_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201913065"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/viw2.7"},{"key":"e_1_2_6_44_1","unstructured":"\u00a0"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202003902"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002791"},{"key":"e_1_2_6_47_1","unstructured":"\u00a0"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201812364"},{"key":"e_1_2_6_48_3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/ange.201812364","volume":"131","year":"2019","journal-title":"Angew. Chem."},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00344J"},{"key":"e_1_2_6_50_1","unstructured":"\u00a0"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b02311"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2012.08.073"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc43867h"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b06637"},{"key":"e_1_2_6_55_1","unstructured":"\u00a0"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b05328"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA12131D"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.201900387"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b00490"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b17051"},{"key":"e_1_2_6_61_1","unstructured":"\u00a0"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b04565"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121817"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200052"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21545"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2011.10.011"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201812387"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201812387"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07027"},{"key":"e_1_2_6_69_1","unstructured":"\u00a0"},{"key":"e_1_2_6_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0343-3"},{"key":"e_1_2_6_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200099"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202001001"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-044952"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx800459q"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr300459d"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71014-w"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-018-2579-6"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr400939q"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00699"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223813"},{"key":"e_1_2_6_81_1","unstructured":"\u00a0"},{"key":"e_1_2_6_82_2","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.9b00102"},{"key":"e_1_2_6_83_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC00774A"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202101007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202101007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202101007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:32:24Z","timestamp":1698024744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202101007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":88,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2021,5,25]]}},"alternative-id":["10.1002\/anie.202101007"],"URL":"https:\/\/doi.org\/10.1002\/anie.202101007","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,22]]},"assertion":[{"value":"2021-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}