{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:37:47Z","timestamp":1792201067330,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21906047"],"award-info":[{"award-number":["21906047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21625503"],"award-info":[{"award-number":["21625503"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Microelectrode\u2010based electrochemical (EC) and photoelectrochemical (PEC) sensors are promising candidates for in vivo analysis of biologically important chemicals. However, limited selectivity in complicated biological systems and poor adaptability to electrochemically non\u2010active species restrained their applications. Herein, we propose the concept of modulating the PEC output by a fluorescence resonance energy transfer (FRET) process. The emission of energy donor was dependent on the concentration of target SO<jats:sub>2<\/jats:sub>, which in turn served as the modulator of the photocurrent signal of the photoactive material. The employment of optical modulation circumvented the problem of selectivity, and the as\u2010fabricated PEC microelectrode showed good stability and reproducibility in vivo. It can monitor fluctuations of SO<jats:sub>2<\/jats:sub>levels in brains of rat models of cerebral ischemia\u2010reperfusion and febrile seizure. More significantly, such a FRET modulated signaling strategy can be extended to diverse analytes.<\/jats:p>","DOI":"10.1002\/anie.202101468","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T04:15:58Z","timestamp":1614744958000},"page":"11774-11778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["FRET Modulated Signaling: A Versatile Strategy to Construct Photoelectrochemical Microsensors for In Vivo Analysis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-3873","authenticated-orcid":false,"given":"Xiaoxue","family":"Ye","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Dai","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytical Science School of Chemistry and Chemical Engineering c\/o School of Civil Engineering Guangzhou University Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Han","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytical Science School of Chemistry and Chemical Engineering c\/o School of Civil Engineering Guangzhou University Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9342","authenticated-orcid":false,"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hubei University Wuhan 430062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0210-106"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1239276"},{"key":"e_1_2_2_4_1","unstructured":"\u00a0"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0060"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.6b00834"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008284"},{"key":"e_1_2_2_7_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202008284"},{"key":"e_1_2_2_8_1","unstructured":"\u00a0"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr068081q"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15692"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr068082i"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac960347d"},{"key":"e_1_2_2_13_1","unstructured":"\u00a0"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1120027"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b00781"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac034573g"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201809992"},{"key":"e_1_2_2_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201809992"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2018.10.017"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00082C"},{"key":"e_1_2_2_20_1","unstructured":"\u00a0"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/35002032"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja025761b"},{"key":"e_1_2_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201907210"},{"key":"e_1_2_2_23_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201907210"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201710863"},{"key":"e_1_2_2_24_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201710863"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b03733"},{"key":"e_1_2_2_26_1","unstructured":"\u00a0"},{"key":"e_1_2_2_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b01504"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46312-4"},{"key":"e_1_2_2_29_1","unstructured":"\u00a0"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557511009011039"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.12.027"},{"key":"e_1_2_2_32_2","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8961951","author":"Huang Y.","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.03.038"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300303q"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/41.6.897"},{"key":"e_1_2_2_36_1","unstructured":"\u00a0"},{"key":"e_1_2_2_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0705871"},{"key":"e_1_2_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01543-X"},{"key":"e_1_2_2_39_1","unstructured":"\u00a0"},{"key":"e_1_2_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.12.042"},{"key":"e_1_2_2_41_2","first-page":"999","volume":"21","author":"Mehrjerdi F. Z.","year":"2018","journal-title":"Iran J. Basic Med. Sci."},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.06.044"},{"key":"e_1_2_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.11.036"},{"key":"e_1_2_2_44_1","unstructured":"\u00a0"},{"key":"e_1_2_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70238-7"},{"key":"e_1_2_2_46_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.162755"},{"key":"e_1_2_2_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017724584"},{"key":"e_1_2_2_48_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-06-0510"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202101468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202101468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202101468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T06:06:53Z","timestamp":1724566013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202101468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":52,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2021,5,17]]}},"alternative-id":["10.1002\/anie.202101468"],"URL":"https:\/\/doi.org\/10.1002\/anie.202101468","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,16]]},"assertion":[{"value":"2021-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}