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However, methods for the synthesis of red phosphorus nanosheets (RPNSs) is lacking, even though red phosphorus (RP) is commercially available at low cost and has excellent chemical stability at room temperature. We report an efficient strategy for fabrication of RPNSs and doped RPNSs using cysteine as a reducing reagent. Data from in\u2005vitro and in\u2005vivo studies suggested that RPNSs can trigger production of reactive oxygen species, DNA damage, and subsequent autophagy\u2010mediated cell death in a shape\u2010dependent manner. 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