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This flexible approach led to both <jats:italic>R<\/jats:italic>\u2010 and <jats:italic>S<\/jats:italic>\u2010enantiomers by fine\u2010tuning of bifunctional phosphonium with excellent selectivity factors (<jats:italic>s<\/jats:italic>) of up to 1057 and 525, respectively. The potential of newly synthesized O\u2010phosphorylated biaryl diols was illustrated by the synthesis of axially chiral organophosphorus compounds. Mechanistic investigations suggest that the bifunctional phosphonium halide catalyst differentiates between the in\u2010situ\u2010generated P\u2010species in the A\u2010T process, mainly involving phosphoryl chloride and phosphoric anhydride, thus leading to highly enantiodivergent O\u2010phosphorylation reactions. Furthermore hydrogen bonding interactions between the catalysts and phosphorus molecules were crucial in asymmetric induction.<\/jats:p>","DOI":"10.1002\/anie.202102352","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T03:13:42Z","timestamp":1615950822000},"page":"14921-14930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":90,"title":["Enantiodivergent Kinetic Resolution of 1,1\u2032\u2010Biaryl\u20102,2\u2032\u2010Diols and Amino Alcohols by Dipeptide\u2010Phosphonium Salt Catalysis Inspired by the Atherton\u2013Todd Reaction"],"prefix":"10.1002","volume":"60","author":[{"given":"Siqiang","family":"Fang","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. China"},{"name":"Hunan Province Key Laboratory of Environmental Catalysis and Waste Recycling College of Materials and Chemical Engineering Hunan Institute of Engineering  Xiangtan 411104 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianke","family":"Pan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. 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