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Herein, we report a strain\u2010release driven synthesis of azetidine\u2010containing spirocycles by harnessing the inherent ring strain of the azabicyclo[1.1.0]butane (ABB) fragment. Novel ABB\u2010ketone precursors bearing silyl\u2010protected alcohols were synthesized in a single step and shown to engage in electrophile\u2010induced spirocyclization\u2010desilylation reactions. Primary, secondary and tertiary silyl ethers were effectively transformed into a library of new spiro\u2010azetidines, with a range of substituents and ring sizes. In addition, the products are generated with synthetically useful ketone and protected\u2010amine functional groups, which provides the potential for further elaboration and for this chemistry to be utilized in the rapid assembly of medicinally relevant compounds.<\/jats:p>","DOI":"10.1002\/anie.202102754","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T03:01:00Z","timestamp":1616468460000},"page":"11824-11829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Strain\u2010Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-1847","authenticated-orcid":false,"given":"Jasper L.","family":"Tyler","sequence":"first","affiliation":[{"name":"School of Chemistry University of Bristol  Cantock's Close Bristol BS8 1TS 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