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Herein, we report the first successful example of ruthenium\u2010catalyzed enantioselective propargylic substitution reactions of propargylic alcohols with diarylphosphine oxides as phosphorus\u2010centered nucleophiles. This synthetic approach provides a new method to prepare chiral phosphorus\u2010containing organic compounds.<\/jats:p>","DOI":"10.1002\/anie.202102779","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T19:17:17Z","timestamp":1617823037000},"page":"11231-11236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Ruthenium\u2010Catalyzed Enantioselective Propargylic Phosphinylation of Propargylic Alcohols with Phosphine Oxides"],"prefix":"10.1002","volume":"60","author":[{"given":"Shiyao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry School of Engineering The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-8656 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