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The following S\n                    <jats:sub>N<\/jats:sub>\n                    2\u2032\u2010addition enables the formation of new 1,3\u2010dipole species having an activated alkene moiety through a second deprotonation process, which then undergo cascade [1+2]\/[3+2] annulations to furnish complex bicyclic [3.1.0]hexane frameworks having three contiguous quaternary stereogenic centers with good to excellent enantioselectivity. Moreover, by using benzoyl aldehyde\u2010derived substrates, a [1+4]\/[3+2] annulation sequence is similarly developed to produce fused cyclopenta[b]furan architectures.\n                  <\/jats:p>","DOI":"10.1002\/anie.202102842","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T04:45:46Z","timestamp":1617857146000},"page":"13913-13917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["A Double Deprotonation Strategy for Cascade Annulations of Palladium\u2013Trimethylenemethanes and Morita\u2013Baylis\u2013Hillman Carbonates to Construct Bicyclo[3.1.0]hexane Frameworks"],"prefix":"10.1002","volume":"60","author":[{"given":"Zhen\u2010Hong","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-0979","authenticated-orcid":false,"given":"Ying\u2010Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University  Chengdu 610041 China"},{"name":"College of Pharmacy Third Military Medical University  Chongqing 400038 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00515a046"},{"key":"e_1_2_2_2_1","unstructured":"For selected reviews 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