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However, the possibilities of formulation of water\u2010insoluble drugs in hydrogels are rather limited. Herein, we assembled recombinant spider silk gels using a new processing route with aqueous\u2013organic co\u2010solvents, and the properties of these gels could be controlled by the choice of the co\u2010solvent. The presence of the organic co\u2010solvent further enabled the incorporation of hydrophobic drugs as exemplarily shown for 6\u2010mercaptopurine. The developed gels showed shear\u2010thinning behaviour and could be easily injected to serve, for example, as drug depots, and they could even be 3D printed to serve as scaffolds for biofabrication. With this new processing route, the formulation of water\u2010insoluble drugs in spider silk\u2010based depots is possible, circumventing common pharmaceutical solubility issues.<\/jats:p>","DOI":"10.1002\/anie.202103147","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T09:32:21Z","timestamp":1616751141000},"page":"11847-11851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Recombinant Spider Silk Gels Derived from Aqueous\u2013Organic Solvents as Depots for Drugs"],"prefix":"10.1002","volume":"60","author":[{"given":"Vanessa J.","family":"Neubauer","sequence":"first","affiliation":[{"name":"Lehrstuhl Biomaterialien Universit\u00e4t Bayreuth  Prof.-R\u00fcdiger-Bormann Strasse 1 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa T.","family":"Trossmann","sequence":"additional","affiliation":[{"name":"Lehrstuhl Biomaterialien Universit\u00e4t Bayreuth  Prof.-R\u00fcdiger-Bormann Strasse 1 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Jacobi","sequence":"additional","affiliation":[{"name":"Lehrstuhl Biomaterialien Universit\u00e4t Bayreuth  Prof.-R\u00fcdiger-Bormann Strasse 1 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"D\u00f6bl","sequence":"additional","affiliation":[{"name":"Lehrstuhl Biomaterialien Universit\u00e4t Bayreuth  Prof.-R\u00fcdiger-Bormann Strasse 1 95447 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-2423","authenticated-orcid":false,"given":"Thomas","family":"Scheibel","sequence":"additional","affiliation":[{"name":"Lehrstuhl Biomaterialien Universit\u00e4t Bayreuth  Prof.-R\u00fcdiger-Bormann Strasse 1 95447 Bayreuth Germany"},{"name":"Bayreuther Zentrum f\u00fcr Kolloide und Grenzfl\u00e4chen (BZKG) Universit\u00e4t Bayreuth  Universit\u00e4tsstrasse 30 95440 Bayreuth Germany"},{"name":"Bayerisches Polymerinstitut (BPI) Universit\u00e4t Bayreuth  Universit\u00e4tsstrasse 30 95440 Bayreuth Germany"},{"name":"Bayreuther Zentrum f\u00fcr Molekulare Biowissenschaften (BZMB) Universit\u00e4t Bayreuth  Universit\u00e4tsstrasse 30 95440 Bayreuth Germany"},{"name":"Bayreuther Materialzentrum (BayMAT) Universit\u00e4t Bayreuth  Universit\u00e4tsstrasse 30 95440 Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00340-5"},{"key":"e_1_2_2_2_1","unstructured":"\u00a0"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200700433"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/7\/4\/045012"},{"key":"e_1_2_2_5_1","unstructured":"\u00a0"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.07.019"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2006.06.007"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.9b01062"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/7\/2\/025001"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi048983q"},{"key":"e_1_2_2_11_1","unstructured":"\u00a0"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm200154k"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2016.07.044"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1515\/pac-2015-0106"},{"key":"e_1_2_2_15_1","unstructured":"\u00a0"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409846"},{"key":"e_1_2_2_16_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201409846"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aa90db"},{"key":"e_1_2_2_18_1","first-page":"1750","volume":"4","author":"Kumari S.","year":"2018","journal-title":"ACS Biomater. 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