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But it is not easy to realize the transformation due to the disruption of the reactive NH\n                    <jats:sub>2<\/jats:sub>\n                    group of glycinates. Inspired by the enzymatic aldol reaction of glycine, we successfully developed an asymmetric aldol reaction of glycinate\n                    <jats:bold>5<\/jats:bold>\n                    and trifluoromethyl ketones\n                    <jats:bold>4<\/jats:bold>\n                    with 0.1\u20130.0033\u2005mol\u2009% of chiral\n                    <jats:italic>N<\/jats:italic>\n                    \u2010methyl pyridoxal\n                    <jats:bold>7\u2009a<\/jats:bold>\n                    as the catalyst, producing chiral \u03b2\u2010trifluoromethyl\u2010\u03b2\u2010hydroxy\u2010\u03b1\u2010amino\u2010acid esters\n                    <jats:bold>6<\/jats:bold>\n                    in 55\u201382\u2009% yields (for the\n                    <jats:italic>syn<\/jats:italic>\n                    \u2010diastereomers) with up to &gt;20:1 dr and 99\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    under very mild conditions. The reaction proceeds via a catalytic cycle similar to the enzymatic aldol reaction of glycine. Pyridoxal catalyst\n                    <jats:bold>7\u2009a<\/jats:bold>\n                    activates both reactants at the same time and brings them together in a specific spatial orientation, accounting for the high efficiency as well as excellent diastereo\u2010 and enantioselectivities.\n                  <\/jats:p>","DOI":"10.1002\/anie.202104031","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T15:25:05Z","timestamp":1623943505000},"page":"20166-20172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Efficient Asymmetric Biomimetic Aldol Reaction of Glycinates and Trifluoromethyl Ketones by Carbonyl Catalysis"],"prefix":"10.1002","volume":"60","author":[{"given":"Aolin","family":"Cheng","sequence":"first","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghai","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Education Ministry Key Lab of Resource Chemistry Joint International Research Laboratory of Resource Chemistry Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials College of Chemistry and Materials Science Shanghai Normal University  Shanghai 200234 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