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The reported transformation features a Pd\u2010catalyzed asymmetric allylic alkylation and a Rh\u2010catalyzed enantioselective 1,4\u2010conjugate addition, effectively converting simple allyl enol carbonate precursors into enantioenriched cyclic ketones with two remote stereocenters. Despite the anticipated challenges associated with controlling stereoselectivity in such a complex system, the products are obtained in enantiomeric excesses ranging up to &gt;99\u2009% <jats:italic>ee<\/jats:italic>, exceeding those obtained from either of the individual asymmetric reactions. In addition, since the stereoselectivity of both steps is under catalyst control, this one\u2010pot reaction is enantio\u2010 and diastereodivergent, enabling facile access to all stereoisomers from the same set of starting materials.<\/jats:p>","DOI":"10.1002\/anie.202105800","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T02:17:22Z","timestamp":1622168242000},"page":"16932-16936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Enantio\u2010 and Diastereodivergent Sequential Catalysis Featuring Two Transition\u2010Metal\u2010Catalyzed Asymmetric Reactions"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-3649","authenticated-orcid":false,"given":"Jeanne","family":"Masson\u2010Makdissi","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St. George Street. Toronto Ontario M5S 3H6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7965-7168","authenticated-orcid":false,"given":"Liher","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St. George Street. Toronto Ontario M5S 3H6 Canada"},{"name":"Department of Organic and Inorganic Chemistry University of the Basque Country (UPV\/EHU)  P.O. Box 644 48080 Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-7617","authenticated-orcid":false,"given":"Xavier","family":"Abel\u2010Snape","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St. George Street. Toronto Ontario M5S 3H6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-2914","authenticated-orcid":false,"given":"Mark","family":"Lautens","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Toronto  80 St. George Street. 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