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However, the chemo\u2010 and enantioselective hydrogenation of the relatively inert unsaturated group in substrates possessing multiple unsaturated bonds remains a challenge. We herein report a protocol for the highly chemo\u2010 and enantioselective hydrogenation of conjugated enynes while keeping the alkynyl bond intact. Mechanism studies indicate that the accompanying Zn\n                    <jats:sup>2+<\/jats:sup>\n                    generated from zinc reduction of the Co\n                    <jats:sup>II<\/jats:sup>\n                    complex plays a critical role to initiate a plausible Co\n                    <jats:sup>I<\/jats:sup>\n                    \/Co\n                    <jats:sup>III<\/jats:sup>\n                    catalytic cycle. This approach allows for the highly efficient generation of chiral propargylamines (up to 99.9\u2009%\n                    <jats:italic>ee<\/jats:italic>\n                    and 2000 S\/C) and further useful chemical transformations.\n                  <\/jats:p>","DOI":"10.1002\/anie.202106566","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T13:56:07Z","timestamp":1622555767000},"page":"16989-16993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Cobalt\u2010Catalyzed Chemo\u2010 and Enantioselective Hydrogenation of Conjugated Enynes"],"prefix":"10.1002","volume":"60","author":[{"given":"Yanhua","family":"Hu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontier Science Center for Transformative Molecules School of Chemistry and Chemical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontier Science Center for Transformative Molecules School of Chemistry and Chemical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China"},{"name":"School of Pharmacy Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-4195","authenticated-orcid":false,"given":"Wanbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontier Science Center for Transformative Molecules School of Chemistry and Chemical Engineering Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China"},{"name":"School of Pharmacy Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"Reviews:"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr100218m"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr200328h"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00564"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800053"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00082E"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020617)41:12<1998::AID-ANIE1998>3.0.CO;2-8"},{"key":"e_1_2_2_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020617)114:12<2096::AID-ANGE2096>3.0.CO;2-Z"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020617)41:12<2008::AID-ANIE2008>3.0.CO;2-4"},{"key":"e_1_2_2_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020617)114:12<2108::AID-ANGE2108>3.0.CO;2-Z"},{"key":"e_1_2_2_10_1","unstructured":"Recent representative examples:"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00985"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912640"},{"key":"e_1_2_2_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201912640"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916534"},{"key":"e_1_2_2_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201916534"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201915459"},{"key":"e_1_2_2_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201915459"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-020-0474-5"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006661"},{"key":"e_1_2_2_16_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202006661"},{"key":"e_1_2_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916677"},{"key":"e_1_2_2_17_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201916677"},{"key":"e_1_2_2_18_1","unstructured":"Recent representative examples:"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903954"},{"key":"e_1_2_2_19_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201903954"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201905263"},{"key":"e_1_2_2_20_3","doi-asserted-by":"crossref","first-page":"11629","DOI":"10.1002\/ange.201905263","volume":"131","year":"2019","journal-title":"Angew. 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