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The IF paradigm states that a substrate \u201cinstructs\u201d the host to change its shape after complexation, while CS asserts that a guest \u201cselects\u201d the optimal fit from an ensemble of preexisting host conformations. With no studies that quantitatively address the interplay of two limiting pathways in abiotic systems, we herein and for the first time describe the way by which twisted capsule\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    , encompassing two conformers\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (+) and\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (\u2212), trap CX\n                    <jats:sub>4<\/jats:sub>\n                    (X=Cl, Br) to give CX\n                    <jats:sub>4<\/jats:sub>\n                    \u2282\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (+) and CX\n                    <jats:sub>4<\/jats:sub>\n                    \u2282\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (\u2212), with all four states being in thermal equilibrium. With the assistance of 2D EXSY, we found that CBr\n                    <jats:sub>4<\/jats:sub>\n                    would, at its lower concentrations, bind\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    via a\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (+)\u2192\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (\u2212)\u2192CBr\n                    <jats:sub>4<\/jats:sub>\n                    \u2282\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    (\u2212) pathway corresponding to conformational selection. For\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                    <\/jats:italic>\n                    \u2010\n                    <jats:bold>1<\/jats:bold>\n                    complexing CCl\n                    <jats:sub>4<\/jats:sub>\n                    though, data from 2D EXSY measurements and 1D NMR line\u2010shape analysis suggested that lower CCl\n                    <jats:sub>4<\/jats:sub>\n                    concentrations would favor CS while the IF pathway prevailed at higher proportions of the guest. Since CS and IF are not mutually exclusive, we reason that our work sets the stage for characterizing the dynamics of a wide range of already existing hosts to broaden our fundamental understanding of their action. The objective is to master the way in which encapsulation takes place for designing novel and allosteric sequestering agents, catalysts and chemosensors akin to those found in nature.\n                  <\/jats:p>","DOI":"10.1002\/anie.202107091","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T16:20:20Z","timestamp":1623687620000},"page":"19942-19948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["From Selection to Instruction and Back: Competing Conformational Selection and Induced Fit Pathways in Abiotic Hosts"],"prefix":"10.1002","volume":"60","author":[{"given":"Radoslav Z.","family":"Pavlovi\u0107","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry The Ohio State University  100 West 18th Avenue Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy F.","family":"Lalisse","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; 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