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The chiral Ir<jats:sup>III<\/jats:sup>\u2010\u03c0\u2010allyl intermediate was separated and characterized to understand the origin of the regio\u2010 and stereoselectivity of the initial C\u2212C bond formation process. Control experiments shed some light on the catalyst\/substrate and catalyst\/catalyst interactions in this dual catalytic system to rationalize the related kinetic\/dynamic kinetic resolution process with different catalyst combinations. The enantioenriched \u03b3\u2010butyrolactone products were converted into an array of structurally complex chiral molecules and organocatalysts that were otherwise inaccessible.<\/jats:p>","DOI":"10.1002\/anie.202107418","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T15:43:27Z","timestamp":1633967007000},"page":"24930-24940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":132,"title":["Stereodivergent Synthesis of Enantioenriched \u03b3\u2010Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis"],"prefix":"10.1002","volume":"60","author":[{"given":"Lu","family":"Xiao","sequence":"first","affiliation":[{"name":"College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds &amp; Materials Ministry of Education, Wuhan University  Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds &amp; Materials Ministry of Education, Wuhan University  Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-6889","authenticated-orcid":false,"given":"Chun\u2010Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds &amp; Materials Ministry of Education, Wuhan University  Wuhan 430072 China"},{"name":"State Key Laboratory of Elemento-organic Chemistry Nankai University  Tianjin 300071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0021-z"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0805"},{"key":"e_1_2_6_4_1","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","volume-title":"Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products","author":"Padwa A.","year":"2003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00113"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB02686B"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr5007182"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC05238K"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.01.002"},{"key":"e_1_2_6_11_1","unstructured":"\u00a0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198500941"},{"key":"e_1_2_6_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19850970206"},{"key":"e_1_2_6_13_2","first-page":"687","volume-title":"Studies in Natural Products Chemistry, Vol.\u200516","author":"Koch S. 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