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However, for most nanozymes, this activity is optimal just in acidic solutions, while the pH of most physiological systems is beyond 7.0 (even &gt;8.0 in chronic wounds) with inadequate H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . We herein communicate an activatable nanozyme with targeting capability to simultaneously break the local pH and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    limitations under physiological conditions. As a proof of concept, aptamer\u2010functionalized nanozymes, glucose oxidase, and hyaluronic acid constitute an activatable nanocapsule \u201cAPGH\u201d, which can be activated by bacteria\u2010secreted hyaluronidase in infected wounds. Nanozymes bind onto bacteria through aptamer recognition, and glucose oxidation tunes the local pH down and supplements H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    for the in\u2010situ generation of\n                    <jats:sup>.<\/jats:sup>\n                    OH on bacteria surfaces. The activity switching and enhanced antibacterial effect of the nanocapsule were verified in\u2005vitro and in diabetic wounds. This strategy for directly regulating local microenvironment is generally accessible for nanozymes, and significant for facilitating biological applications of nanozymes.\n                  <\/jats:p>","DOI":"10.1002\/anie.202107712","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T23:42:42Z","timestamp":1628638962000},"page":"23534-23539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["A Glucose\u2010Powered Activatable Nanozyme Breaking pH and H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    Limitations for Treating Diabetic Infections"],"prefix":"10.1002","volume":"60","author":[{"given":"Lifang","family":"Chen","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Cytochemistry School of Chemistry and Biological Engineering Changsha University of Science and Technology  Changsha 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