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They are composed of a trialdehyde core reversibly linked to a diamine PEG connector and to a variety of neutral, anionic, or cationic heads, to generate a library of DCFs to generate multivalent dendritic architectures in the presence of Pseudomonas aeruginosa and Staphylococcus aureus. The best DCFs were always polycationic and the nature of the cationic heads significantly impact the antibiofilm activity. The best antibiofilm activity was observed for <jats:bold>DCF3B<\/jats:bold>, displaying a polyethyleneimine head. A simple inactive guanidinium functional head strongly inhibited biofilm growth when assayed as a multivalent <jats:bold>DCF3C<\/jats:bold>. Using a more advanced in vitro biofilm model of chronic wound infection, <jats:bold>DCF3C<\/jats:bold> was found significantly superior than all other DCFs. 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