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Their mitigation desires controllable activation of CAR\u2010T cells that is achievable through regulatory display of CARs. By embedding the hepatitis C virus NS3 protease (HCV\u2010NS3) between the single\u2010chain variable fragment (scFv) and the hinge domain, we showed that the display of anti\u2010CD19 scFv on CAR\u2010T cells was positively correlated to the presence of a clinical HCV\u2010NS3 inhibitor asunaprevir (ASV). This novel CAR design that allows the display of anti\u2010CD19 scFv in the presence of ASV and its removal in the absence of ASV creates a practically reversible chemical switch. 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