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However, noninvasively in vivo monitoring reactive species specifically within alkaline tissue remains a huge challenge. Here we introduce a dual activatable fluorescent probe PN910 located in the second near\u2010infrared window (NIR\u2010II, 900\u20131700\u2005nm), which shows high selectivity toward H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and OONO\n                    <jats:sup>\u2212<\/jats:sup>\n                    at pH beyond 7.4. Then we verified that PN910 could be used for the real\u2010time, specific and accurate monitoring of cystitis and colitis for living animals. This report presents a unique approach to the development of dual activatable probe for in vivo biosensing.\n                  <\/jats:p>","DOI":"10.1002\/anie.202109728","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T19:03:47Z","timestamp":1633374227000},"page":"26337-26341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":176,"title":["ROS\/RNS and Base Dual Activatable Merocyanine\u2010Based NIR\u2010II Fluorescent Molecular Probe for in vivo Biosensing"],"prefix":"10.1002","volume":"60","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem Fudan University  Shanghai 200433 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