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Mechanism studies reveal that the migration is triggered by the alkene addition of fluoroalkyl radical derived from the electron donor\u2010acceptor (EDA) complex of Togni's reagent II or fluoroalkyl iodides and quinuclidine, and involves a unique 5(6)\u2010exo\u2010trig cyclization of the carbon\u2010centered radical onto the N\u2010atom of ketoxime ethers followed by a cascade sequence of N\u2212O bond cleavage and dehydrogenation. Notably, besides Togni's reagent II and fluoroalkyl iodides, this protocol is also compatible with other radical precursors to provide various functionalized primary aminoketones.<\/jats:p>","DOI":"10.1002\/anie.202110583","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T17:25:18Z","timestamp":1629998718000},"page":"26308-26313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Radical 1,4\/5\u2010Amino Shift Enables Access to Fluoroalkyl\u2010Containing Primary \u03b2(\u03b3)\u2010Aminoketones under Metal\u2010Free Conditions"],"prefix":"10.1002","volume":"60","author":[{"given":"Dian","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou 730000 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