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Many DEL synthesis protocols hinge on sequential additions of monomers using split\u2010pool combinatorial methods. Therefore, compatible protecting group strategies that allow the unmasking of reactive functionality (e.\u2009g. amines and alcohols) prior to monomer coupling, or the removal of less desirable functionality (e.\u2009g., alkenes and alkynes) are highly desirable. Hydrogenation\/hydrogenolysis procedures would achieve these ends but have not been amenable to DEL chemistry. We report a catalytic hydrogen transfer reaction using Pd\/C, HCONH<jats:sub>4<\/jats:sub> and the micelle\u2010forming surfactant, TPGS\u2010750\u2010M, which gives highly efficient conversions for hydrogenolysis of Cbz\u2010protected amines and benzyl protected alcohols and hydrogenation of nitros, halides, nitriles, aldehydes, alkenes and alkynes. Application to multicycle synthesis of an encoded compound was fully compatible with DNA\u2010amplification and sequencing, demonstrating its applicability to DEL synthesis. 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