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Herein, we report the selection and optimization of a new DNAzyme for\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (SA) and the use of the DNAzyme to develop a simple lateral flow device (LFD) for detection of SA in nasal mucus. The DNAzyme was generated by in vitro selection using a crude extra\/intracellular mixture derived from SA, which could be used directly for simple solution or paper\u2010based fluorescence assays for SA. The DNAzyme was further modified to produce a DNA cleavage fragment that acted as a bridging element to bind DNA\u2010modified gold nanoparticles to the test line of a LFD, producing a simple colorimetric dipstick test. The LFD was evaluated with nasal mucus samples spiked with SA, and demonstrated that SA detection was possible in minutes with minimal sample processing.\n                  <\/jats:p>","DOI":"10.1002\/anie.202112346","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:40:44Z","timestamp":1637707244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["A Lateral Flow Test for\n                    <i>Staphylococcus aureus<\/i>\n                    in Nasal Mucus Using a New DNAzyme as the Recognition Element"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6308-2205","authenticated-orcid":false,"given":"M. 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