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However, low enhancement factor (EF) limits its practical applications for trace detection. Here, a novel sponge\u2010like Cu\u2010doping SnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NiO p\u2010n semiconductor heterostructure (SnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NiO\n                    <jats:sub>x<\/jats:sub>\n                    \/Cu), was first created as a CM\u2010based SERS substrate with a significant EF of 1.46\u00d710\n                    <jats:sup>10<\/jats:sup>\n                    . This remarkable EF was mainly attributed to the enhanced charge\u2010separation efficacy of p\u2010n heterojunction and charge transfer resonance resulted from Cu doping. Moreover, the porous structure enriched the probe molecules, resulting in further SERS signals magnification. By immobilizing CuPc as an inner\u2010reference element, SnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010NiO\n                    <jats:sub>x<\/jats:sub>\n                    \/Cu was developed as a SERS nose for selective recognition of multiple lung cancer related VOCs down to ppb level. The information of VOCs was recorded in a barcode, demonstrating practical potential of a desktop SERS device for biomarker screening.\n                  <\/jats:p>","DOI":"10.1002\/anie.202112367","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T19:32:57Z","timestamp":1633635177000},"page":"26260-26267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Ultrasensitive Sensing of Volatile Organic Compounds Using a Cu\u2010Doped SnO\n                    <sub>2<\/sub>\n                    \u2010NiO p\u2010n Heterostructure That Shows Significant Raman Enhancement**"],"prefix":"10.1002","volume":"60","author":[{"given":"Yan","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Precision Spectroscopy East China Normal University  Dongchuan Road 500 Shanghai 200241 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-0349","authenticated-orcid":false,"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Precision Spectroscopy East China Normal University  Dongchuan Road 500 Shanghai 200241 China"},{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 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