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This photocascade is initiated by the excited state intramolecular proton transfer (ESIPT) in aromatic amino ketones with tethered dual unsaturated pendants, i.e. pyrrole and alkenic moieties, resulting in the formation of four \u03c3\u2010bonds and setting six new stereogenic centers in a single experimentally simple photochemical step with up to 220\u2005mcbit complexity increases.<\/jats:p>","DOI":"10.1002\/anie.202112573","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T03:26:44Z","timestamp":1638329204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maximizing Step\u2010Normalized Increases in Molecular Complexity: Formal [4+2+2+2] Photoinduced Cyclization Cascade to Access Polyheterocycles Possessing Privileged Substructures"],"prefix":"10.1002","volume":"61","author":[{"given":"D. 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