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Herein we report our efforts on merging two ARA reactions into a single\u2010step transformation. Catalyzed by a complex formed from iridium and a steric hindered phosphoramidite, readily available and inexpensive aromatic ketones initially undergo the first ARA with ammonium acetate to afford primary amines, which serve as the amine sources for the second ARA, and finally provide the enantiopure <jats:italic>C<\/jats:italic><jats:sub>2<\/jats:sub>\u2010symmetric secondary amine products. The developed process competently enables the successive coupling of inorganic and organic nitrogen sources with ketones in the same reaction system. The Br\u00f8nsted acid additive plays multiple roles in this procedure: it accelerates the formation of imine intermediates, minimizes the inhibitory effect of N\u2010containing species on the iridium catalyst, and reduces the primary amine side products.<\/jats:p>","DOI":"10.1002\/anie.202112671","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T12:35:28Z","timestamp":1635251728000},"page":"27307-27311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["An Iridium Catalytic System Compatible with Inorganic and Organic Nitrogen Sources for Dual Asymmetric Reductive Amination Reactions"],"prefix":"10.1002","volume":"60","author":[{"given":"Zhaofeng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Chemistry Shaanxi Key Laboratory of Natural Products &amp; Chemical Biology Northwest A&amp;F University  22 Xinong Road Yangling Shaanxi 712100 P. R. 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