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Synthesis was achieved using the target bisquaternary amine NMBAs as a template to link two highly anionic <jats:italic>p<\/jats:italic>\u2010sulfonatocalixarene building blocks in aqueous solution. Bivalent anionic hosts <jats:bold>Super\u2010sCx4<\/jats:bold> and <jats:bold>Super\u2010sCx5<\/jats:bold> bind by engaging both quaternary amines present on a variety of NMBAs. We report low \u03bcM binding to structurally diverse alkyl, steroidal, curarine and benzylisoquinoline NMBAs with high selectivity over the neurotransmitter acetylcholine and a variety of other hydrophobic amines.<\/jats:p>","DOI":"10.1002\/anie.202113235","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T07:55:20Z","timestamp":1638345320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Template\u2010Directed Synthesis of Bivalent, Broad\u2010Spectrum Hosts for Neuromuscular Blocking Agents**"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-8686","authenticated-orcid":false,"given":"Allison J.","family":"Selinger","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Victoria  3800 Finnerty Rd. 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