{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:29:08Z","timestamp":1780388948089,"version":"3.54.1"},"reference-count":115,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","award":["IBS-R010-A2"],"award-info":[{"award-number":["IBS-R010-A2"]}],"id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The site\u2010selective C\u2212H functionalization of heteroarenes is of considerable importance for streamlining the rapid modification of bioactive molecules. Herein, we report a general strategy for visible\u2010light\u2010induced \u03b2\u2010carbonyl alkylation at the C4 position of pyridines with high site selectivity using various cyclopropanols and N\u2010amidopyridinium salts. In this process, hydrogen\u2010atom transfer between the generated sulfonamidyl radicals and O\u2212H bonds of cyclopropanols generates \u03b2\u2010carbonyl radicals, providing efficient access to synthetically valuable \u03b2\u2010pyridylated (aryl)ketones, aldehydes, and esters with broad functional\u2010group tolerance. In addition, the mild method serves as an effective tool for the site\u2010selective late\u2010stage functionalization of complex and medicinally relevant molecules.<\/jats:p>","DOI":"10.1002\/anie.202113658","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T02:54:48Z","timestamp":1635994488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Visible\u2010Light\u2010Induced C4\u2010Selective Functionalization of Pyridinium Salts with Cyclopropanols"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2953-9053","authenticated-orcid":false,"given":"Mari","family":"Vellakkaran","sequence":"first","affiliation":[{"name":"Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science (IBS)"},{"name":"Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST)  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-1350","authenticated-orcid":false,"given":"Taehwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science (IBS)"},{"name":"Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST)  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9371-1730","authenticated-orcid":false,"given":"Sungwoo","family":"Hong","sequence":"additional","affiliation":[{"name":"Center for Catalytic Hydrocarbon Functionalizations Institute for Basic Science (IBS)"},{"name":"Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST)  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"\u00a0"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00021"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1260212"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1md00134e"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja1066459"},{"key":"e_1_2_6_6_1","unstructured":"\u00a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232993"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm4017625"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.11.050"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol027437r"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.06.135"},{"key":"e_1_2_6_13_1","unstructured":"Recent 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