{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:33:22Z","timestamp":1792107202196,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21874152, 22174162"],"award-info":[{"award-number":["21874152, 22174162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21790390, 21790391"],"award-info":[{"award-number":["21790390, 21790391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In vivo microelectrodes are essential for neuroscience studies. However, development of microelectrodes with both flexibility and multifunctionality for recording chemical and electrical signals in the same extracellular microspace and modulating neural activity remains challenging. Here, we find that pure PEDOT:PSS fibers (i.e., support\u2010free) exhibit high conductivity, fast heterogeneous electron transfer, and suitable charge storage and injection capabilities, and can thus directly act as microelectrodes not only for chemical and electrophysiological recording in the same extracellular microspace, but also for electromodulation of neural microcircuit activity. Moreover, the microelectrodes mechanically match with neural tissues, exhibiting less foreign body responses. Given the multifunctionality, flexibility, and biocompatibility, the support\u2010free PEDOT:PSS\u2010based microelectrodes offer a new avenue to microelectrode technology for neuroscience research, diagnostics and therapeutics.<\/jats:p>","DOI":"10.1002\/anie.202115074","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T06:30:11Z","timestamp":1644388211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Support\u2010Free PEDOT:PSS Fibers as Multifunctional Microelectrodes for In Vivo Neural Recording and Modulation"],"prefix":"10.1002","volume":"61","author":[{"given":"Tianci","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-9321","authenticated-orcid":false,"given":"Lanqun","family":"Mao","sequence":"additional","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7061-6025","authenticated-orcid":false,"given":"Meining","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Renmin University of China  Beijing 100872 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","volume-title":"The Oxford handbook of event-related potential components","author":"Luck S. J.","year":"2011"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3708"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2901"},{"key":"e_1_2_7_5_1","unstructured":"\u00a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav2842"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b20542"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202010675"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202010675"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008284"},{"key":"e_1_2_7_9_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202008284"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao6750"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.591311"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b04456"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00789.2010"},{"key":"e_1_2_7_14_1","unstructured":"\u00a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/micronano.2015.2"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/micronano.2017.70"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b08327"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6223(95)00057-K"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810827115"},{"key":"e_1_2_7_21_1","unstructured":"\u00a0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(03)00255-5"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70059-1"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1254"},{"key":"e_1_2_7_25_1","unstructured":"\u00a0"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201802560"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3468"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06084-6"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201000900"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201401608"},{"key":"e_1_2_7_31_1","unstructured":"\u00a0"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800923"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2019.104027"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201900662"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1000"},{"key":"e_1_2_7_36_1","unstructured":"\u00a0"},{"key":"e_1_2_7_37_2","volume-title":"Neuromodulation: comprehensive textbook of principles, technologies, and therapies","author":"Krames E. S.","year":"2018"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b02296"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00829-5"},{"key":"e_1_2_7_40_1","unstructured":"\u00a0"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-6779(98)00315-4"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav9492"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.24331"},{"key":"e_1_2_7_44_1","volume-title":"Electrochemical Methods: Fundamentals and Applications","author":"Bard A. J.","year":"2001"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200462750"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200462750"},{"key":"e_1_2_7_46_1","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/35083500"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/1124"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.008"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705900"},{"key":"e_1_2_7_50_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201705900"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1205"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408484111"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2388-4"},{"key":"e_1_2_7_54_1","unstructured":"\u00a0"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.295341"},{"key":"e_1_2_7_56_2","first-page":"4","volume":"8","author":"Zhang Z.","year":"2009","journal-title":"Biomed. Eng."},{"key":"e_1_2_7_57_1","unstructured":"\u00a0"},{"key":"e_1_2_7_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3264"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1376-17.2017"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1919"},{"key":"e_1_2_7_61_1","unstructured":"\u00a0"},{"key":"e_1_2_7_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/35072519"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1117"},{"key":"e_1_2_7_64_1","unstructured":"\u00a0"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.04.038"},{"key":"e_1_2_7_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4925"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.038"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202115074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202115074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202115074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:41:16Z","timestamp":1692628876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202115074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":71,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,4,11]]}},"alternative-id":["10.1002\/anie.202115074"],"URL":"https:\/\/doi.org\/10.1002\/anie.202115074","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]},"assertion":[{"value":"2021-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202115074"}}