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Two heterogeneous catalysts have been developed for the synthesis, and the key step involves reductive amination of nitriles using dimethylpolysilane\u2010modified Pd on activated carbon\/calcium phosphate. Overall, (<jats:italic>R<\/jats:italic>)\u2010tamsulosin was obtained in 60\u2009% yield and 64\u2009% ee (99\u2009% ee after recrystallization) in a flow stream through four catalytic transformations without the need for the isolation or purification of any intermediates or byproduct.<\/jats:p>","DOI":"10.1002\/anie.202115643","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T02:58:28Z","timestamp":1642993108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Continuous\u2010Flow Synthesis of (<i>R<\/i>)\u2010Tamsulosin Utilizing Sequential Heterogeneous Catalysis"],"prefix":"10.1002","volume":"61","author":[{"given":"Yuki","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Science The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-0033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Science The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-0033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Laroche","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Science The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-0033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruro","family":"Ishitani","sequence":"additional","affiliation":[{"name":"Green &amp; Sustainable Chemistry Social Cooperation Laboratory Graduate School of Science The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-0033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8235-4368","authenticated-orcid":false,"given":"Sh\u016b","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Science The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-0033 Japan"},{"name":"Green &amp; Sustainable Chemistry Social Cooperation Laboratory Graduate School of Science The University of Tokyo  Hongo, Bunkyo-ku Tokyo 113-0033 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"S. 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