{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:03:12Z","timestamp":1790740992702,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21837006"],"award-info":[{"award-number":["21837006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91953117"],"award-info":[{"award-number":["91953117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177141"],"award-info":[{"award-number":["22177141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010342"],"award-info":[{"award-number":["2021A1515010342"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of the tumor microenvironment to achieve a satisfactory anti\u2010tumor immune effect. We designed a carbonic anhydrase IX (CAIX)\u2010anchored rhenium(I) photosensitizer, named\n                    <jats:bold>CA\u2010Re<\/jats:bold>\n                    , that not only performs type\u2010I and type\u2010II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar\u2010level phototoxicity), but also evokes gasdermin D (GSDMD) mediated pyroptotic cell death to effectively stimulate tumor immunogenicity.\n                    <jats:bold>CA\u2010Re<\/jats:bold>\n                    could disrupt and self\u2010report the loss of membrane integrity simultaneously. This promoted the maturation and antigen\u2010presenting ability of dendritic cells (DCs), and fully activated T cells dependent adaptive immune response in vivo, eventually eliminating distant tumors at the same time as destroying primary tumors. To the best of our knowledge,\n                    <jats:bold>CA\u2010Re<\/jats:bold>\n                    is the first metal complex\u2010based pyroptosis inducer.\n                  <\/jats:p>","DOI":"10.1002\/anie.202115800","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T05:06:12Z","timestamp":1638162372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":217,"title":["A Carbonic Anhydrase IX (CAIX)\u2010Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti\u2010Tumor Immunity"],"prefix":"10.1002","volume":"61","author":[{"given":"Xuxian","family":"Su","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-2942","authenticated-orcid":false,"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyi","family":"Ling","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Zhou","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-1154","authenticated-orcid":false,"given":"Zong\u2010Wan","family":"Mao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry State Key Laboratory of Oncology in South China Sun Yat-Sen University  Guangzhou 510275 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8172"},{"key":"e_1_2_6_2_1","unstructured":"\u00a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00950-z"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011273"},{"key":"e_1_2_6_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202011273"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008604"},{"key":"e_1_2_6_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202008604"},{"key":"e_1_2_6_6_1","unstructured":"\u00a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1894"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00221"},{"key":"e_1_2_6_9_1","unstructured":"\u00a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00211"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0328-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b13620"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007878"},{"key":"e_1_2_6_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202007878"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014959"},{"key":"e_1_2_6_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202014959"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b00186"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3pp50333j"},{"key":"e_1_2_6_17_1","unstructured":"\u00a0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904914"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-020-9846-4"},{"key":"e_1_2_6_20_1","unstructured":"\u00a0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06663"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b00715"},{"key":"e_1_2_6_23_1","unstructured":"\u00a0"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01050-0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b04371"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-010-0479-7"},{"key":"e_1_2_6_27_1","unstructured":"\u00a0"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22393"},{"key":"e_1_2_6_30_1","unstructured":"\u00a0"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18590"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.797217"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_6_34_1","unstructured":"\u00a0"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120142"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201907267"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2071-9"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2079-1"},{"key":"e_1_2_6_39_1","unstructured":"\u00a0"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16143-6"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016399"},{"key":"e_1_2_6_41_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202016399"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101840"},{"key":"e_1_2_6_43_1","unstructured":"\u00a0"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04315"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0826-3"},{"key":"e_1_2_6_46_1","unstructured":"\u00a0"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.71"},{"key":"e_1_2_6_49_1","unstructured":"\u00a0"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02396"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903968"},{"key":"e_1_2_6_51_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201903968"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax0937"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202005362"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202005362"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.009"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202115800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202115800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202115800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:51:08Z","timestamp":1693209068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202115800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,2,14]]}},"alternative-id":["10.1002\/anie.202115800"],"URL":"https:\/\/doi.org\/10.1002\/anie.202115800","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,23]]},"assertion":[{"value":"2021-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202115800"}}