{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:21:42Z","timestamp":1791613302739,"version":"4.3.4"},"reference-count":75,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIGMS, R01GM084019"],"award-info":[{"award-number":["NIGMS, R01GM084019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the first example of selective Pd<jats:sup>II<\/jats:sup>\u2010catalyzed tertiary C\u2212H activation of cyclobutylmethyl ketones using a transient directing group. An electron\u2010deficient 2\u2010pyridone ligand was identified as the optimal external ligand to enable tertiary C\u2212H activation. A variety of cyclobutylmethyl ketones bearing quaternary carbon centers was readily accessed without preinstalling internal directing groups in up to 81\u2009% yield and &gt;95\u2009:\u20095 regioisomeric ratios of tertiary C\u2212H arylation to \u03b2\u2010methylene (\u03b2\u2010methyl) or \u03b3\u2010C\u2212H arylation.<\/jats:p>","DOI":"10.1002\/anie.202117233","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T03:14:48Z","timestamp":1643858088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Palladium(II)\u2010Catalyzed Selective Arylation of Tertiary C\u2212H Bonds of Cyclobutylmethyl Ketones Using Transient Directing Groups"],"prefix":"10.1002","volume":"61","author":[{"given":"Jin\u2010Tang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Chemistry The Scripps Research Institute  10550 North Torrey Pines Road La Jolla CA 92037 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