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However, the scope of available alkenes is limited to styrenes, activated alkenes, and compounds with directing groups. The catalytic enantioselective hydroboration of heteroatom\u2010substituted alkenes is rarely explored and those catalyzed by earth\u2010abundant metals are yet to be reported. Herein, we report a cobalt\u2010catalyzed asymmetric hydroboration of ketone\u2010derived silyl enol ethers and provide a convenient approach to access valuable enantiopure \u03b2\u2010hydroxy boronic esters. This protocol features mild reaction conditions, a broad substrate scope, and excellent enantioselectivities (up to 99\u2009% ee). This approach was applied in the successful synthesis of salmeterol and albuterol, demonstrating its potential to streamline complex molecule synthesis.<\/jats:p>","DOI":"10.1002\/anie.202117413","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T04:40:10Z","timestamp":1651293610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Enantioselective Cobalt\u2010Catalyzed Hydroboration of Ketone\u2010Derived Silyl Enol Ethers"],"prefix":"10.1002","volume":"61","author":[{"given":"Wenke","family":"Dong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemo\/Biosensing and Chemometrics Advanced Catalytic Engineering Research Center of the Ministry of Education College of Chemistry and Chemical Engineering Hunan University  Changsha Hunan 410082 P. R. 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