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A knowledge gap in stabilizing molecular Ti\n                    <jats:sup>4+<\/jats:sup>\n                    species in aqueous environments has prevented the use of this ion for various applications such as radioimaging, design of water\u2010compatible metal\u2013organic frameworks (MOFs), and aqueous\u2010phase catalysis applications. Herein, we show a thorough thermodynamic screening of bidentate chelators with Ti\n                    <jats:sup>4+<\/jats:sup>\n                    in aqueous solution, as well as computational and structural analyses of key compounds. In addition, the hexadentate analogues of catechol (benzene\u20101,2\u2010diol) and deferiprone (3\u2010hydroxy\u20101,2\u2010dimethyl\u20104(1\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010pyridone), TREN\u2010CAM and THP\n                    <jats:sup>Me<\/jats:sup>\n                    respectively, were assessed for chelation of the\n                    <jats:sup>45<\/jats:sup>\n                    Ti isotope (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    =3.08\u2005h, \u03b2\n                    <jats:sup>+<\/jats:sup>\n                    =85\u2009%, E\n                    <jats:sub>\u03b2+<\/jats:sub>\n                    =439\u2005keV) towards positron emission tomography (PET) imaging applications. Both were found to have excellent capacity for kit\u2010formulation, and [\n                    <jats:sup>45<\/jats:sup>\n                    Ti]Ti\u2010TREN\u2010CAM was found to have remarkable stability in vivo.\n                  <\/jats:p>","DOI":"10.1002\/anie.202201211","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T09:29:34Z","timestamp":1646818174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A General Design Strategy Enabling the Synthesis of Hydrolysis\u2010Resistant, Water\u2010Stable Titanium(IV) Complexes"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3000-8201","authenticated-orcid":false,"given":"Angus J.","family":"Koller","sequence":"first","affiliation":[{"name":"Department of Chemistry Stony Brook University Stony Brook NY 11794 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shefali","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham Birmingham AL 25294 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-3594","authenticated-orcid":false,"given":"Ivis F.","family":"Chaple","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Alabama at Birmingham Birmingham AL 25294 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7446-6004","authenticated-orcid":false,"given":"M. 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