{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:37:35Z","timestamp":1788403055103,"version":"build-2803163510"},"reference-count":90,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R01GM124414-01A1"],"award-info":[{"award-number":["1R01GM124414-01A1"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A strategy to access diverse multisubstituted acrylamides from cyclic ketones is realized via palladium\/norbornene\u2010catalyzed \u03b1\u2010carbamoylation and <jats:italic>ipso<\/jats:italic>\u2010functionalization of the corresponding enol triflates. The development of bulky C2 secondary amide\u2010substituted norbornene cocatalysts is the key to achieve the desired reactivity and selectivity. Readily available carbamoyl chlorides serve as effective electrophiles; various moieties including alkenyl, hydrogen, alkynyl, aryl, and alkyl groups can be installed at the <jats:italic>ipso<\/jats:italic> position. In addition, tandem \u03b1\u2010carbamoylation\/<jats:italic>ipso<\/jats:italic>\u2010annulations are demonstrated to furnish lactam\u2010containing polycyclic scaffolds. The utility of this method is exemplified in the streamlined preparation of a platelet\u2010activating factor (PAF)\u2010antagonist.<\/jats:p>","DOI":"10.1002\/anie.202201239","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T03:25:09Z","timestamp":1645673109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Rapid Access to Multisubstituted Acrylamides from Cyclic Ketones via Palladium\/Norbornene Cooperative Catalysis"],"prefix":"10.1002","volume":"61","author":[{"given":"Zhao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Chemistry the University of Chicago  5735 S Ellis Ave Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-6015","authenticated-orcid":false,"given":"Guangbin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Chemistry the University of Chicago  5735 S Ellis Ave Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","volume-title":"Advanced Organic Chemistry Part B: Reaction and Synthesis","author":"Carey F. 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