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By using the \u201cbottom\u2010up\u201d synthetic strategy, we synthesized three azulene\u2010embedded [\n                    <jats:italic>n<\/jats:italic>\n                    ]helicenes (\n                    <jats:bold>\n                      [\n                      <jats:italic>n<\/jats:italic>\n                      ]AzHs\n                    <\/jats:bold>\n                    ,\n                    <jats:italic>n<\/jats:italic>\n                    =5, 6 and 7), in which one terminal azulene subunit was fused with\n                    <jats:italic>n<\/jats:italic>\n                    \u2010\n                    <jats:italic>2<\/jats:italic>\n                    benzene rings.\n                    <jats:italic>P\u2010<\/jats:italic>\n                    and\n                    <jats:italic>M\u2010<\/jats:italic>\n                    enantiomers were observed in the packing diagrams of\n                    <jats:bold>[5]\u2010<\/jats:bold>\n                    , and\n                    <jats:bold>[6]AzHs<\/jats:bold>\n                    . However,\n                    <jats:italic>\n                      <jats:bold>P<\/jats:bold>\n                      \u2010\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      <jats:bold>M<\/jats:bold>\n                      \u2010\n                    <\/jats:italic>\n                    <jats:bold>[7]AzHs<\/jats:bold>\n                    could be isolated by recrystallization of the racemic mixture. These\n                    <jats:bold>\n                      [\n                      <jats:italic>n<\/jats:italic>\n                      ]AzHs\n                    <\/jats:bold>\n                    were endowed with new properties through the azulene moiety such as low\u2010lying first electric state (S\n                    <jats:sub>1<\/jats:sub>\n                    ), small optical energy gap and\n                    <jats:italic>anti\u2010<\/jats:italic>\n                    Kasha emission.\n                    <jats:bold>[6]\u2010<\/jats:bold>\n                    , and\n                    <jats:bold>[7]AzHs<\/jats:bold>\n                    exhibit strong chiroptical responses with high absorption dissymmetry factor (g\n                    <jats:sub>abs<\/jats:sub>\n                    ) maxima of about 0.02, which is among the highest |g\n                    <jats:sub>abs<\/jats:sub>\n                    | values of helicenes in the visible range. These azulene\u2010embedded [\n                    <jats:italic>n<\/jats:italic>\n                    ]helicenes contribute to the non\u2010benzenoid helicene library and allow the structure\u2013property relationships to be better understood.\n                  <\/jats:p>","DOI":"10.1002\/anie.202201494","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:48:44Z","timestamp":1645487324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Azulene\u2010Embedded [\n                    <i>n<\/i>\n                    ]Helicenes (\n                    <i>n<\/i>\n                    =5, 6 and 7)"],"prefix":"10.1002","volume":"61","author":[{"given":"Chao","family":"Duan","sequence":"first","affiliation":[{"name":"Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai 201203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Xiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodi","family":"Yang","sequence":"additional","affiliation":[{"name":"Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine  Shanghai 201203 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Numbers\u20052141362 ([5]AzH) 2141366 ([6]AzH) 2141367 (M-[7]AzH) and 2141368 (P-[7]AzH)contain the supplementarycrystallographic data for this paper. 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