{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:24:15Z","timestamp":1790047455633,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["Nos. ZYYC21002"],"award-info":[{"award-number":["Nos. ZYYC21002"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["No. ZYJC1803"],"award-info":[{"award-number":["No. ZYJC1803"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXCX06"],"award-info":[{"award-number":["2019HXCX06"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["No. 2018-CY02-00042-GX"],"award-info":[{"award-number":["No. 2018-CY02-00042-GX"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sulfide and persulfide are chemically different and one might expect persulfide to be more effective in mediating sulfur signaling because persulfide can directly modify protein cysteine residue. However, rapid scrambling, and interconversions occur among sulfur species. Then there is the question of whether the chemical reactivity differences between sulfide and persulfide would translate into pharmacological differences. Utilizing a delivery system to generate pure hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), hydrogen persulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    ), and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl\u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010cysteine persulfide (\n                    <jats:italic>N<\/jats:italic>\n                    \u2010CysSSH), we examined the activities of sulfide and persulfide in vitro and in vivo. Persulfide prodrugs exhibited increased activities compared to the H\n                    <jats:sub>2<\/jats:sub>\n                    S prodrug. In particular, the H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>2<\/jats:sub>\n                    prodrug offers much\u2010elevated analgesic effects compared to the H\n                    <jats:sub>2<\/jats:sub>\n                    S prodrug in vivo. Persulfide prodrugs also possess a reduced level of toxicity compared to the H\n                    <jats:sub>2<\/jats:sub>\n                    S prodrug in vivo, indicating persulfide might represent a better therapeutic paradigm than H\n                    <jats:sub>2<\/jats:sub>\n                    S.\n                  <\/jats:p>","DOI":"10.1002\/anie.202201668","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T03:03:32Z","timestamp":1645844612000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Prodrugs of Persulfide and Sulfide: Is There a Pharmacological Difference between the Two in the Context of Rapid Exchanges among Various Sulfur Species In Vivo\n                    <i>?<\/i>"],"prefix":"10.1002","volume":"61","author":[{"given":"Bingchen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State University  Atlanta GA 30303 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology West China Hospital Sichuan University  Chengdu 610041 Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology West China Hospital Sichuan University  Chengdu 610041 Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology West China Hospital Sichuan University  Chengdu 610041 Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology West China Hospital Sichuan University  Chengdu 610041 Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-7719","authenticated-orcid":false,"given":"Bowen","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology West China Hospital Sichuan University  Chengdu 610041 Sichuan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00205"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21433"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20234"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03516J"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01518K"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.06.004"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1405665111"},{"key":"e_1_2_3_11_1","unstructured":"\u00a0"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321232111"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01311-y"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11004-7"},{"key":"e_1_2_3_15_1","unstructured":"\u00a0"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7889"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3391"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509277112"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190514"},{"key":"e_1_2_3_20_1","unstructured":"\u00a0"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/c4ob00868e"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.672816"},{"key":"e_1_2_3_23_1","unstructured":"\u00a0"},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b09795"},{"key":"e_1_2_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500968"},{"key":"e_1_2_3_26_1","unstructured":"\u00a0"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2011.01.044"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5041"},{"key":"e_1_2_3_29_1","unstructured":"\u00a0"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201803087"},{"key":"e_1_2_3_30_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201803087"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08469"},{"key":"e_1_2_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201704117"},{"key":"e_1_2_3_32_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201704117"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b03471"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b01224"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7880"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202010530"},{"key":"e_1_2_3_36_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202010530"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014052"},{"key":"e_1_2_3_37_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202014052"},{"key":"e_1_2_3_38_1","unstructured":"\u00a0"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00340"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.11.009"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(80)90346-9"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.09.015"},{"key":"e_1_2_3_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02611"},{"key":"e_1_2_3_44_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01962"},{"key":"e_1_2_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126903"},{"key":"e_1_2_3_46_1","unstructured":"\u00a0"},{"key":"e_1_2_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.01.024"},{"key":"e_1_2_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2016.08.004"},{"key":"e_1_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014050"},{"key":"e_1_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2899"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511244"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201511244"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12180"},{"key":"e_1_2_3_53_1","unstructured":"\u00a0"},{"key":"e_1_2_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.05.013"},{"key":"e_1_2_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.007"},{"key":"e_1_2_3_56_1","unstructured":"\u00a0"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-36"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.091595"},{"key":"e_1_2_3_59_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.106435"},{"key":"e_1_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226415"},{"key":"e_1_2_3_61_1","unstructured":"\u00a0"},{"key":"e_1_2_3_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073363"},{"key":"e_1_2_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2017.01.012"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217740859"},{"key":"e_1_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.103699"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)01441-1"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2012.11.006"},{"key":"e_1_2_3_68_1","first-page":"25","volume-title":"Methods in Enzymology, Vol.\u2005143","author":"Wood J. L.","year":"1987"},{"key":"e_1_2_3_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja505371z"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202201668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202201668","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202201668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:47:53Z","timestamp":1773816473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202201668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":74,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2022,5,9]]}},"alternative-id":["10.1002\/anie.202201668"],"URL":"https:\/\/doi.org\/10.1002\/anie.202201668","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]},"assertion":[{"value":"2022-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202201668"}}