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We report a platform for developing ionophores from metal\u2010ion chelators, which are readily available with wide\u2010ranging affinities and specificities, and structural data that can aid rational design. Specifically, we fine\u2010tuned the binding affinity and lipophilicity of a Zn<jats:sup>II<\/jats:sup>\u2010chelating ligand by introducing silyl groups proximal to the Zn<jats:sup>II<\/jats:sup>\u2010binding pocket, which generated ionophores that performed better than most of the currently known Zn<jats:sup>II<\/jats:sup> ionophores. Furthermore, these silicon\u2010based ionophores were specific for Zn<jats:sup>II<\/jats:sup> over other metals and exhibited better antibacterial activity and less toxicity to mammalian cells than several known Zn<jats:sup>II<\/jats:sup> ionophores, including pyrithione. These studies establish rational design principles for the rapid development of potent and specific ionophores and a new class of antibacterial agents.<\/jats:p>","DOI":"10.1002\/anie.202201698","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T13:16:44Z","timestamp":1649251004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Rational Design of Silicon\u2010Based Zinc Ionophores"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7563-0176","authenticated-orcid":false,"given":"Kei","family":"Yamada","sequence":"first","affiliation":[{"name":"Chemical Biology and Therapeutics Science Broad Institute of MIT and Harvard  Cambridge MA 02142 USA"},{"name":"Department of Medicine Harvard Medical School  Boston MA 02115 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