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Developing efficient methods for preparing phosphorus compounds with these privileged motifs is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method by a chiral\u2010phosphonium\u2010salt\u2010catalyzed novel cascade between phosphorus\u2010containing nitroolefins and \u03b1,\u03b1\u2010dicyanoolefins, leading to a great diversity of atropisomeric biaryls bearing phosphorus groups in high yields with excellent stereoselectivities. The reaction features include a Thorpe\u2010type cycloaddition\/oxidative hydroxylation\/aromatization cascade pathway with a central\u2010to\u2010axial chirality transfer process. Insight gained from our studies is expected to advance general efforts towards the catalytic synthesis of atropisomeric biaryl phosphorus compounds, offering a platform for developing new efficient chiral ligands and catalysts.<\/jats:p>","DOI":"10.1002\/anie.202202467","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T13:55:19Z","timestamp":1652363719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Enantioselective Synthesis of Atropisomeric Biaryl Phosphorus Compounds by Chiral\u2010Phosphonium\u2010Salt\u2010Enabled Cascade Arene Formation"],"prefix":"10.1002","volume":"61","author":[{"given":"Lixiang","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Green Chemistry &amp; Technology of Ministry of Education College of Chemistry Sichuan University  29 Wangjiang Road Chengdu 610064 P. R. 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