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For example, while PKC is unable to downregulate the activity of a gain\u2010of\u2010function variant (S180A) of Bruton's tyrosine kinase that evokes B cell malignancy phenotype, PHICS enabled PKC to induce inhibitory neo\u2010phosphorylations on this variant. Furthermore, while PKC typically phosphorylates its membrane\u2010associated substrates, PKC with PHICS phosphorylated multiple cytosol\u2010based neo\u2010substrates (e.g., BCR\u2010ABL). Finally, a PHICS for BCR\u2010ABL induced death of chronic myeloid leukemia cell lines. These studies show the power of synthetic chemistry to expand the chemical and functional diversity of proteins in cells using bifunctional molecules.\n                  <\/jats:p>","DOI":"10.1002\/anie.202202770","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T22:31:26Z","timestamp":1654036286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0402-7414","authenticated-orcid":false,"given":"Veronika M.","family":"Shoba","sequence":"first","affiliation":[{"name":"Chemical Biology and Therapeutics Science Program Broad Institute of MIT and Harvard  Cambridge MA 02142 USA"},{"name":"Department of Medicine Harvard Medical School  Boston MA 02115 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanushka N. 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