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We report a prodrug design concept for metal complexes, termed \u201cmetal\u2010carrying prochelator\u201d, which can co\u2010carry a metal ion and chelator within a single small\u2010molecule compound and remain inert until it undergoes a specifically triggered intramolecular chelation to synthesize a bioactive metal complex in situ for targeted therapy. As a proof\u2010of\u2010concept, we designed a H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>\u2010responsive small\u2010molecule prochelator, DPBD, based on the strong chelator diethyldithiocarbamate (DTC) and copper. DPBD can carry Cu<jats:sup>2+<\/jats:sup> (DPBD\u2010Cu) and respond to elevated H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> levels in tumor cells by releasing DTC, which rapidly chelates Cu<jats:sup>2+<\/jats:sup> from DPBD\u2010Cu affording a DTC\u2013copper complex with high cytotoxicity, realizing potent antitumor efficacy with low systemic toxicity. 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