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Various 2,2\u2010disubstituted 3\u2010carbonyl indoles with a stereogenic quaternary carbon center were synthesized from 2\u2010substituted indoles in yields up to 78\u2009% with good enantio\u2010 and diastereoselectivities (up to 96\u2009:\u20094 e.r. and &gt;20\u2009:\u20091 d.r.). This unprecedented protocol demonstrated that hydrolase catalysis is compatible with electrosynthesis, and the reaction can be carried out in organic solvents with a broad substrate scope and good stereoselectivity. This work provides insights into enzymatic electrosynthesis.<\/jats:p>","DOI":"10.1002\/anie.202203666","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T13:28:32Z","timestamp":1653658112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Merging the Non\u2010Natural Catalytic Activity of Lipase and Electrosynthesis: Asymmetric Oxidative Cross\u2010Coupling of Secondary Amines with Ketones"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-1255","authenticated-orcid":false,"given":"Chao\u2010Jiu","family":"Long","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Chemistry of Chongqing Municipality School of Chemistry and Chemical Engineering Southwest University  Chongqing 400715 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