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A wide range of aryl and heteroatom aryl halides, vinyl bromides, alkynyl bromides, and acyl chlorides react with unhindered and hindered aldehyde\u2010derived\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010oxy halides by providing protected alcohols as well as \u03b1\u2010hydroxy ketones. Noteworthy, the reductive couplings are achieved not only through thermal catalysis with the use of metal reductants but also by photocatalysis, electrochemistry, and mechanochemistry. The unrestricted interchange of the four strategies indicates their underlying mechanistic similarities. The generation of Ni\n                    <jats:sup>I<\/jats:sup>\n                    intermediate is proposed to be the key point for ketyl radical formation via a single\u2010electron transfer (SET) event, which was rationalized by an array of control experiments and density functional theory (DFT) calculations.\n                  <\/jats:p>","DOI":"10.1002\/anie.202204212","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T10:25:33Z","timestamp":1657535133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Reductive Cross\u2010Coupling of \u03b1\u2010Oxy Halides Enabled by Thermal Catalysis, Photocatalysis, Electrocatalysis, or Mechanochemistry"],"prefix":"10.1002","volume":"61","author":[{"given":"Chen","family":"Zhu","sequence":"first","affiliation":[{"name":"KAUST Catalysis Center (KCC) King Abdullah University of Science and Technology (KAUST)  Thuwal 23955-6900 Saudi 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