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Herein, we designed the light\u2010driven motor molecule\n                    <jats:bold>MC2<\/jats:bold>\n                    , which provides new design criteria to overcome these challenges.\n                    <jats:bold>MC2<\/jats:bold>\n                    forms a selective K\n                    <jats:sup>+<\/jats:sup>\n                    channel through a single molecular transmembrane mechanism, and the light\u2010driven rotary motion significantly accelerates ion transport, which endows the irradiated motor molecule with excellent cytotoxicity and cancer cell selectivity. Mechanistic studies reveal that the rotary motion of\n                    <jats:bold>MC2<\/jats:bold>\n                    promotes K\n                    <jats:sup>+<\/jats:sup>\n                    efflux, generates reactive oxygen species and eventually activates caspase\u20103\u2010dependent apoptosis in cancer cells. Combined with the spatiotemporally controllable advantages of light, we believe this strategy can be exploited in the structural design and application of next\u2010generation synthetic cation transporters for the treatment of cancer and other diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.202204605","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T09:40:20Z","timestamp":1650447620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["A Light\u2010Driven Molecular Machine Controls K\n                    <sup>+<\/sup>\n                    Channel Transport and Induces Cancer Cell Apoptosis"],"prefix":"10.1002","volume":"61","author":[{"given":"Huiting","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize 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