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The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti\u2010virals. Within the international Covid19\u2010NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80\u2009% of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR\u2010detected binding sites of the main protease and the computational procedure. 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