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Reported in this study is a new non\u2010heme Mn catalyst stabilized by a bipiperidine\u2010based tetradentate ligand, which enables methylene oxidation of benzylic compounds by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , showing high activity and excellent chemoselectivity under mild conditions. The protocol tolerates an unprecedentedly wide range of functional groups, including carboxylic acid and derivatives, ketone, cyano, azide, acetate, sulfonate, alkyne, amino acid, and amine units, thus providing a low\u2010cost, more sustainable and robust pathway for the facile synthesis of ketones, increase of complexity of organic molecules, and late\u2010stage modification of drugs.\n                  <\/jats:p>","DOI":"10.1002\/anie.202205983","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T12:31:21Z","timestamp":1653049881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Chemoselective Oxyfunctionalization of Functionalized Benzylic Compounds with a Manganese Catalyst"],"prefix":"10.1002","volume":"61","author":[{"given":"Jimei","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education and 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